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Denmark Shows Success of HIV Treatment as Prevention Among Gay Men

A study by researchers at the University of California at Los Angeles and Copenhagen University Hospital provides the first unambiguous evidence of a link between high rates of viral suppression among gay men and falling HIV incidence, or the proportion of men who catch HIV each year.

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Study Sheds New Light on What Happens During Acute HIV Infection

An individual's HIV viral load set-point is generally reached about a month after plasma viremia is first detectable, according to an analysis published in the May 18 online edition of the New England Journal of Medicine. The RV217 study, which included more than 100 people with acute HIV infection in East Africa and Thailand, found that signs and symptoms were uncommon during the earliest stages of infection, and what happens during this period influences later disease progression.

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U.S. On Course to End Its HIV Epidemic -- Eventually

If current trends continue, the U.S. may eventually end its HIV epidemic, a mathematical model recently published in AIDS and Behavior shows. In 2009, the average number of people each person with HIV would infect during their lifetime fell below 1, and has now declined to 0.75, the model shows. This means the number of people living with HIV will eventually start to shrink, as more aging HIV-positive people start to die than new people getting infected. For the moment, however, since mortality among people with HIV also continues to fall, the number of people living with the virus continues to grow slowly.

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Experimental HIV Vaccine to Enter Large Clinical Trial in South Africa

An investigational vaccine that showed promise in an earlier study will advance to a large-scale efficacy trial at 15 sites in South Africa, the U.S. National Institutes of Health (NIH) announced on May 18, marking HIV Vaccine Awareness Day. The new trial, HVTN 702, designed to determine if the vaccine is safe, well-tolerated, and effective at preventing HIV infection, is due to start this November, with results expected in 4 years.

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Diagnosis of Early HIV Infections May Have Contributed to Fall in Incidence in San Diego

An HIV testing program targeting individuals with acute or early infection likely contributed to a decline in incident or new infections in San Diego after 2008, investigators report in the May 11 online edition of Clinical Infectious Diseases. The Early Test initiative involved negative HIV antibody tests being rescreened using nucleic acid testing (NAT) -- a technique capable of detecting new HIV infections within 7-10 days after exposure.

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HIV Prevalence and New Infections Highest Among Gay Men in Southern U.S.

The burden of HIV in the U.S. is disproportionately high for gay and bisexual men -- who account for about two-thirds of all newly diagnosed infections each year -- and HIV prevalence and new infections among men who have sex with men (MSM) is highest in states in the southeast, according to a new analysis published recently in the Journal of Medical and Internet Research -- Public Health and Surveillance.

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Model Suggests There Are Fewer People with HIV in U.S. and More on Treatment

A study comparing recorded diagnoses of HIV with subsequent records of viral load and CD4 T-cell tests suggests that the number of people living with HIV in the U.S. could have been overestimated by as much as 45% -- and the proportion who are on antiretroviral therapy (ART) with undetectable viral loads could have been underestimated by as much as 50%. There could be as few as 820,000 people with HIV in the U.S. compared with the normally accepted figure of 1.2 million -- and up to 55% of those could be on ART and virally suppressed, compared with the most commonly quoted figure of 30%.

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