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Report Looks at Global State of Harm Reduction for People Who Inject Drugs

Harm Reduction International this month released the latest edition of its Global State of Harm Reduction report, mapping responses to drug-related HIV, hepatitis C, and tuberculosis epidemics around the world. The report looks at prevention interventions by region, including needle and syringe programs, opioid substitution therapy, harm reduction in prisons, overdose response, and access to antiretroviral therapy (ART) for people who inject drugs.

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CROI 2015: Retrovirus Conference Now Underway in Seattle

The 2015 Conference on Retroviruses and Opportunistic Infections (CROI) takes place this week, February 23-26, at the Washington State Convention Center in Seattle. CROI focuses on HIV treatment, prevention, and basic science. For the past several years it has also included substantial hepatitis C content, and this year will feature presentations on Ebola virus. HIVandHepatitis.com is on site in Seattle all week bringing you news coverage and Twitter updates (@HIVandHepatitis).

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Progress and Problems in the Search for a Cure for HIV

Leading experts discussed the latest developments in the search for an HIV cure at a January 13 Center for AIDS Research symposium in San Francisco, following a year of disappointing setbacks in the field. Researchers are increasingly focusing on a "functional cure" -- or remission -- that would allow people with HIV to remain off antiretroviral therapy (ART) for prolonged periods, as the hopes for true viral eradication have dimmed.

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CROI 2015: Retrovirus Conference Starts Monday in Seattle

The 2015 Conference on Retroviruses and Opportunistic Infections (CROI) takes place next week, February 23-26, at the Washington State Convention Center in Seattle. CROI focuses on HIV treatment, prevention, and basic science. For the past several years it has also included substantial hepatitis C content, and this year will feature presentations on Ebola virus. HIVandHepatitis.com will be on site in Seattle all week bringing you news coverage and Twitter updates (@HIVandHepatitis).

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New Clues about Viral Rebound in Mississippi Child Thought Cured of HIV

Clinicians involved in the care of a child many once hoped was cured of HIV have published details about the case in the February 15 New England Journal of Medicine. The authors found that the virus that eventually returned after the girl had been off antiretroviral therapy for more than 2 years was identical to her mother's viral strain.

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Researchers May Have Caught HIV Becoming More Virulent in Cuba

A study from Cuba, recently published online in EBioMedicine, has generated wide media interest because researchers have identified a particular variety of the virus, dubbed CRF19_cpx, that is associated with rapid post-diagnosis drops in CD4 T-cell count and progression to AIDS. In the study, all of the still relatively small minority of people with this viral variant progressed to clinically defined AIDS within 3 years of infection. The variant also seems to be becoming more common in Cuba and may partly explain what appears to be an increase in the proportion of people who progress rapidly to AIDS. However, it is not a drug-resistant strain and antiretroviral therapy (ART) works just as well against it as it does against any other strain of HIV.

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Novel Entry Inhibitor May Provide Vaccine-like Protection Against HIV

A potential new therapy using a molecule that mimics both the CD4 receptor and the CCR5 co-receptor can stop an HIV-like virus from entering host cells, researchers reported in the February 18 online edition of Nature. Monkeys given gene therapy to produce the eCD4-Ig protein did not become infected after repeated virus exposures, suggesting it may be an effective HIV vaccine alternative as well as a long-acting therapy.

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