Coinfection

AASLD 2015: U.S. Faces Biggest Burden of Hepatitis C Treatment Costs Before 2020

The cost of treating hepatitis C is likely to decline dramatically over the next decade in the U.S., not because of cuts in drug prices, but because the population in need of treatment will shrink by 2020 as a majority of patients will already have been treated, according to research by Jagpreet Chhatwal of Massachusetts General Hospital and colleagues presented at the AASLD Liver Meeting in San Francisco last month.

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AASLD 2015: Grazoprevir/ Elbasvir Cures More than 90% of People with HIV/HCV Coinfection

Merck's grazoprevir/elbasvir combination cured 93% of people with HIV and hepatitis C coinfection, was well-tolerated, and did not appear to interact with antiretrovirals, according to final results from the C-EDGE Co-infection study presented at the 2015 AASLD Liver Meeting last month in San Francisco. These results confirm that HIV/HCV coinfected people respond as well to interferon-free therapy as those with HCV alone.

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EACS 2015: Sofosbuvir/ Ledipasvir for 8 Weeks Cures Most Hard-to-Treat Hepatitis C in Real Life

Most hepatitis C patients in the GECCO German hepatitis C cohort who were treated with sofosbuvir/ledipasvir (Harvoni) for 8 weeks in a real-world clinical setting achieved sustained virological response, even those who are advised to stay on treatment for 12 weeks due to factors such as liver cirrhosis, prior treatment experience, and high HCV viral load, according to a presentation last week at the 15th European AIDS Conference in Barcelona.

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Coverage of the 2015 AASLD Liver Meeting

HIVandHepatitis.com coverage of the 2015 American Association for the Study of Liver Diseases (AASLD) Liver Meeting in San Francisco, November 13-17, 2015.

Conference highlights include interferon-free therapy for hepatitis C, treatment for difficult-to-treat populations including people with HCV genotype 3 and liver  cirrhosis, hepatitis B prevention and treatment, and management of advanced liver disease.

Full listing by topic

Liver Meeting website

11/23/15

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Coverage of the 15th European AIDS Conference

HIVandHepatitis.com coverage of the 15th European AIDS Conference, sponsored by the European AIDS Clinical Society (EACS), October 21-14, 2015, in Barcelona.

Conference highlights include antiretroviral therapy and treatment strategies, new European HIV treatment guidelines, HIV pre-exposure prophylaxis (PrEP), and treatment for hepatitis C.

Full listing by topic

15th European AIDS Conference website

10/28/15

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EACS 2015: Hepatitis C Incidence Remains Stable Among HIV-Positive Gay Men in Europe

Researchers have seen no decline in new hepatitis C virus (HCV) infections among HIV-positive men who have sex with men in 16 European CASCADE cohorts, according to a poster presented at the 15th European AIDS Conference last week in Barcelona. However, trends seem to differ between various regions of Europe.

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IDWeek 2015: Sofosbuvir + Daclatasvir Demonstrates High Cure Rates for HIV/HCV Coinfected People

Nearly all people with HIV and genotype 1-4 HCV coinfection treated for 12 weeks with an interferon-free regimen of sofosbuvir (Sovaldi) plus daclatasvir (Daklinza) achieved sustained virological response in the ALLY-2 trial, but 8 weeks did not work as well, according to a report in the August 20 New England Journal of Medicine. Substudies presented this month at IDWeek 2015 showed that this regimen is highly effective regardless of race or specific antiretroviral regimen.

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EACS 2015: Successful Hepatitis C Treatment Lowers Risk of Death for HIV/HCV Coinfected People

Hepatitis C treatment that leads to sustained virological response (SVR) -- generally regarded as a cure -- was associated with a reduced risk of liver-related death and improved overall survival in an analysis of 3500 HIV and hepatitis C virus (HCV) coinfected patients, according to a presentation at the 15th European AIDS Conference last week in Barcelona. A related study found that while some liver-related events are declining over time, liver cancer remains a risk for coinfected people.

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Abacavir/Lamivudine Could Be Driving Liver Damage in People with HIV/HCV Coinfection

Progression of liver fibrosis among ART-treated patients with HIV/HCV coinfection is associated with the type of nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) "backbone," Canadian research published in the September 23 online edition of Clinical Infectious Diseases suggests.

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