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Pre-exposure Prophylaxis (PrEP)

2 Cases of PrEP Failure on Solo Tenofovir Pose Research Questions

A report originally presented to the 2015 British HIV Association conference last year details 2 cases where therapeutic levels of tenofovir used alone for hepatitis B treatment unequivocally failed to prevent HIV infection in gay men. In one case, despite the tenofovir apparently suppressing the man’s HIV viral load in his blood plasma, it failed to prevent HIV infecting the cells of his immune system.

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PrEP Plus Increased Testing and Treatment Could Halve HIV Infections Among UK Gay Men

A new British mathematical modeling study published in The Lancet HIV has found that adding pre-exposure prophylaxis (PrEP) for gay men in the U.K. at high risk of HIV to relatively modest increases in HIV testing and immediate treatment for those diagnosed could substantially cut the number of gay men infected by 2020.alt

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No New HIV Infections Among Consistent Truvada Users in PrEP Demo Project

HIV incidence was "extremely low" in a pre-exposure prophylaxis (PrEP) demonstration project at community-based clinics in Miami, San Francisco, and Washington, DC, and no new infections were seen among gay and bisexual men who took Truvada (tenofovir/emtricitabine) at least twice a week, according to a report in the January 26 edition of JAMA Internal Medicine. PrEP adherence was higher among people at greater risk for HIV.

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Lessons Learned from the History of Contraception are Relevant for HIV PrEP Implementation

Achieving widespread and appropriate use of HIV pre-exposure prophylaxis (PrEP) will take several years and will require considerable attention to the shape and quality of health services, according to a commentary in the January edition ofCurrent Opinion in HIV and AIDS from researchers who have looked at the way in which contraceptive methods have been introduced.

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2. More Evidence Shows PrEP Is Highly Effective

Pre-exposure prophylaxis (PrEP) was again a major HIV story in the mainstream media in 2015, amid growing evidence that it is highly effective both in research studies and in real-world practice when taken consistently.

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